New anthracycline antibiotics, rhodirubins.
نویسندگان
چکیده
منابع مشابه
Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains.
New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against...
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Previous fluorescence microscopic studies have shown daunorubicin (DNR) and Adriamycin (ADR) are localized in cell nuclei, whereas trifluoroacetyladriamycin-14-valerate is local ized in the cytoplasm. Using cultured cells, we correlated structural characteristics of a series of anthracycline antibiotics with cellular disposition and metabolic response. When ob served under fluorescence microsco...
متن کاملTHE JOURNAL OF ANTIBIOTICS Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains
+ Institute of Organic Chemistry, Tammannstraße 2, D-37077 Göttingen, Germany ++ Division of Clinical Mycology, National Institute of Health, Department of Medical Science, Nonthaburi, Thailand +++ Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-City, Chiba (260), Japan ‡ Labor für Bodenmikrobiologie, Burggarten 9, D-35102 Lohra-Kir...
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Microbial 4-O-methylation using a specific daunorubicin-blocked, nonproducing mutant provided the new anthracycline antibiotics 4-O-methylbetaclamycin T, 4-Omethylyellamycin A and 4-0-methyl1 3-hydroxyoxaunomycin, from which 4-0-methyloxaunomycin and 4-O-methyl-6deoxyoxaunomycin were then prepared by further photochemical 7V-demethylation. Antitumor activities in vitro and in vivo against L1210...
متن کاملIsolation of New Anthracycline
Sir: During the course of our screening program for new anthracycline antibiotics, four /5-rhodomycinone glycosides, A447 A, B, C and D were found in the acetone extract of cultured mycelia of a strain designated as A447. Based on NMR spectral analysis and chemical degradation, A447 A and B were identified as cosmomycins D and C1^, respectively, while A447 C and D were found to be new congeners...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1977
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.30.616